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Cialis Tadalafil 20mgis a popular prescription medication for treating erectile dysfunction (ED) in men. This ED drug is designed to provide a more natural and spontaneous sexual activity. It offers a higher concentration of tadalafil than the original, but it works just as well for longer erections. The active ingredient, Tadalafil, is a phosphodiesterase type 5 (PDE5) inhibitor. It has the same active ingredient as sildenafil (Viagra), but it is not affected by food. It is important to note that Cialis does not work for every man and that it is not suitable for everyone. It may not work for everyone, but it helps to treat erectile dysfunction in men of certain age groups (age, sex drive, etc).

Cialis Tadalafil 20mg Side Effects

In some cases, the side effects of Cialis may include the following:Headache, flushing, indigestion, back pain, muscle pain, nasal congestion, indigestion, upset stomach, nasal congestion, dizziness, diarrhea, dizziness, abnormal vision, blurred vision, back pain, muscle pain, nausea, vomiting, blurred vision, vision changes, nasal congestion, blurred vision, nasal congestion, diarrhea, nasal congestion, indigestion, chest pain, itching, and flushing. These side effects should disappear as your body adjusts to the medication.

Tadalafil 20mg Precautions and Side Effects

If you experience a severe or sudden erection lasting longer than four hours, stop the medication and seek medical attention immediately. This medication should not be used by men with anatomical deformation of penis, Peyronie's disease, or any other medical condition. It may not work for you, and you may suffer from vision loss, dizziness, or fainting. If you have any of these serious side effects, stop treatment and consult your doctor. If you experience an erection that lasts more than four hours, seek medical attention immediately.

Read the Patient Information Leaflet if available from your pharmacist before you start taking tadalafil, and each time you get a refill, add in the dose, and the frequency of use. Take tadalafil exactly as directed. Do not take more than one dose of tadalafil per day. If you miss a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not take two doses at the same time.If you miss a dose, take it as soon as possible. If it is almost time for the next dose, seek medical attention immediately.The most common side effects are:Headache, flushing, indigestion, back pain, muscle pain, nasal congestion, dizziness, diarrhea, dizziness, gas, abnormal vision, blurred vision, back pain, muscle pain, itching, and flushing.Read the Patient Information Leaflet If you have a dosing schedule, your healthcare provider may ask you certain questions about how you can safely use tadalafil. Read the Patient Information Leaflet from the pharmacy or check for updated information on tadalafil. If you have any concerns about taking tadalafil, talk to your doctor, pharmacist, or a pharmacist from your doctor’s office. Pharmacies may also ask you whether you should take it, and if taking it, and do not take it more than once a day. Pharmacies will not use these dosing questions to answer your health condition or to provide any advice about using tadalafil. You must talk to a doctor or pharmacist who knows you and can help determine the best way to use tadalafil.

Tadalafil Storage

Keep tadalafil in a cool, dry place, out of the reach of children. Throw away any medication that contains alcohol and household waste, and dispose of it in a>pot. You should not flush this medication down the toilet. You can alsonotget rid of tadalafil if you do not have it.

Read the Patient Information Leaflet from the pharmacy or have it sent toPharmacy of Americafor disposal.

Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

• Ketoconazole, itraconazole (used to manage fungal infection)
• Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
• Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
• Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
• Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.

Main Interactions:

Cialis and nitrates are atherosthy zero (an action that averages out to 3000-5250 minutes in medical trials). While they act similar, their bodies sometimes have a misdiagnoseness. Here are the key drug-food interactions:

Top Drug-Food Interactions with Cialis

Cialis (tadalafil) is a potent, FDA-approved drug with adocumented history of causing significant and possibly life-threatening side effects.

References

1. KD. Tripathi. Androgens and Drugs for Erectile Dysfunction. Essentials of medical pharmacology. Seventh edition. 2013. Page-304.

2. Adam M Henrie, James J Nawarskas, and Joe R Anderson. Clinical utility of tadalafil in the treatment of pulmonary arterial hypertension: an evidence-based review. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. November 2015. [Accessed on November 08th, 2023]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636095/

3. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in October 2021] [Accessed on November 08th, 2023]https://www.medicines.org.uk/emc/files/pil.8637.pdf

4. Leeford Healthcare Private Ltd. Bigfun-36.https://www.leeford.in/product/556/bigfun-36

5. Central Drugs Standard Control Organization. Tadalafil tablet 20 mg (Additional Indication). [Revised in November 2009]. Tadalafil 10mg/20mg Tablets. [Revised in September 2003] [Accessed on November 08th, 2023]https://cdscoonline.gov.in/CDSCO/Drugs

Central drug regulatory organisation

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Sherry D’Amico, “The Erectile Dysfunction Market in the UK is expected to reach USD 2.2 billion by 2033”.

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